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KMID : 0882420160900060545
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Korean Journal of Medicine
2016 Volume.90 No. 6 p.545 ~ p.549
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De Novo AL Amyloidosis in a Renal Allograft
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Hwang Ji-Yeon
Lee Dong-Ryeol
An Jung-Myung
Kim Sung-Jun
Kim Dong-Kyu
Park Min-Gi
Park Su-Ho
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Abstract
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Amyloidosis is characterized by the extracellular deposition of amyloid in various tissues and organs, particularly the kidney and heart. The estimated incidence of systemic amyloidosis is at least 8 per million population per year. However, few cases of systemic amyloidosis in renal allografts have been reported. A stable renal transplant recipient was admitted with proteinuria and dyspnea on exertion. The M-peak was found on serum and urine protein electrophoresis, and lambda (λ) dominance was confirmed by serum and urine free-light-chain test. The patient was diagnosed with systemic amyloidosis of a renal allograft, by allograft biopsy, at 22 years after renal transplantation. We report a case of AL amyloidosis in a stable renal allograft and review the medical literature.
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KEYWORD
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De novo AL amyloidosis, Kidney allograft, Kidney biopsy, Immunoglobulin light chains
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